A genetic programming-based convolutional deep learning algorithm for identifying COVID-19 cases via X-ray images.

Evolutionary algorithms have been successfully employed to find the best structure for many learning algorithms including neural networks. Due to their flexibility and promising results, Convolutional Neural Networks (CNNs) have found their application in many image processing applications. The structure of CNNs greatly affects the performance of these algorithms both in terms of accuracy and computational cost, thus, finding the best architecture for these networks is a crucial task before they are employed. In this paper, we develop a genetic programming approach for the optimization of CNN structure in diagnosing COVID-19 cases via X-ray images. A graph representation for CNN architecture is proposed and evolutionary operators including crossover and mutation are specifically designed for the proposed representation. The proposed architecture of CNNs is defined by two sets of parameters, one is the skeleton which determines the arrangement of the convolutional and pooling operators and their connections and one is the numerical parameters of the operators which determine the properties of these operators like filter size and kernel size. The proposed algorithm in this paper optimizes the skeleton and the numerical parameters of the CNN architectures in a co-evolutionary scheme. The proposed algorithm is used to identify covid-19 cases via X-ray images.

Mathematical Modeling of COVID-19 Spread Using Genetic Programming Algorithm

This paper analyses the possibilities of using Machine learning to develop a forecasting model for COVID-19 with a publicly available dataset from the Johns Hopkins University COVID-19 Data Repository and with the addition of a percentage of each variant from the GISAID Variant database. Genetic programming (GP), a symbolic regressor algorithm, is used for the estimation of new confirmed infected cases, hospitalized cases, cases in intensive care units (ICUs), and deceased cases. This metaheuristics method algorithm was used on a dataset for Austria and neighboring countries Czechia, Hungary, Slovenia, and Slovakia. Machine learning was done to create individual models for each country. Variance-based sensitivity analysis was initiated using the obtained mathematical models. This analysis showed us which input variables the output of the obtained models is sensitive to, like in the case of how much each covid variant affects the spread of the virus or the number of deceased cases. Individual short-term models have achieved very high R2 scores, while long-term predictions have achieved lower R2 scores. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

An automated machine learning model for diagnosing COVID-19 infection

The coronavirus disease 2019 (COVID-19) epidemic still impacts every facet of life and necessitates a fast and accurate diagnosis. The need for an effective, rapid, and precise way to reduce radiologists' workload in diagnosing suspected cases has emerged. This study used the tree-based pipeline optimization tool (TPOT) and many machine learning (ML) algorithms. TPOT is an open-source genetic programming-based AutoML system that optimizes a set of feature preprocessors and ML models to maximize classification accuracy on a supervised classification problem. A series of trials and comparisons with the results of ML and earlier studies discovered that most of the AutoML beat traditional ML in terms of accuracy. A blood test dataset that has 111 variables and 5644 cases were used. In TPOT, 450 pipelines were used, and the best pipeline selected consisted of radial basis function (RBF) Sampler preprocessing and Gradient boosting classifier as the best algorithm with a 99% accuracy rate. © 2023, Institute of Advanced Engineering and Science. All rights reserved.

Forecasting the spread of SARS-CoV-2 in the campania region using genetic programming.

Coronavirus disease 19 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus, which is responsible for the ongoing global pandemic. Stringent measures have been adopted to face the pandemic, such as complete lockdown, shutting down businesses and trade, as well as travel restrictions. Nevertheless, such solutions have had a tremendous economic impact. Although the use of recent vaccines seems to reduce the scale of the problem, the pandemic does not appear to finish soon. Therefore, having a forecasting model about the COVID-19 spread is of paramount importance to plan interventions and, then, to limit the economic and social damage. In this paper, we use Genetic Programming to evidence dependences of the SARS-CoV-2 spread from past data in a given Country. Namely, we analyze real data of the Campania Region, in Italy. The resulting models prove their effectiveness in forecasting the number of new positives 10/15 days before, with quite a high accuracy. The developed models have been integrated into the context of SVIMAC-19, an analytical-forecasting system for the containment, contrast, and monitoring of Covid-19 within the Campania Region.

Disease-Ligand Identification Based on Flexible Neural Tree.

In order to screen the disease-related compounds of a traditional Chinese medicine prescription in network pharmacology research accurately, a new virtual screening method based on flexible neural tree (FNT) model, hybrid evolutionary method and negative sample selection algorithm is proposed. A novel hybrid evolutionary algorithm based on the Grammar-guided genetic programming and salp swarm algorithm is proposed to infer the optimal FNT. According to hypertension, diabetes, and Corona Virus Disease 2019, disease-related compounds are collected from the up-to-date literatures. The unrelated compounds are chosen by negative sample selection algorithm. ECFP6, MACCS, Macrocycle, and RDKit are utilized to numerically characterize the chemical structure of each compound collected, respectively. The experiment results show that our proposed method performs better than classical classifiers [Support Vector Machine (SVM), random forest (RF), AdaBoost, decision tree (DT), Gradient Boosting Decision Tree (GBDT), KNN, logic regression (LR), and Naive Bayes (NB)], up-to-date classifier (gcForest), and deep learning method (forgeNet) in terms of AUC, ROC, TPR, FPR, Precision, Specificity, and F1. MACCS method is suitable for the maximum number of classifiers. All methods perform poorly with ECFP6 molecular descriptor.

COVID-19 Spread Prediction and Its Impact on the Stock market price

Predicting the Covid-19 spread and its impact on the stock market is an important research challenge these days. In order to obtain the best forecasting model, we have exploited neuro-evolutionary technique Cartesian genetic programming evolved artificial neural network (CGPANN) based solution to predict the future cases of COVID-19 up to 6-days in advance. This helps authorities and paramedical staff to take precautionary measures on time which helps in counteracting the spreading of the virus. The rising number of COVID cases has caused a significant impact on the stock market. CGPANN being the best performer for the time series prediction model seems ideal for the case under consideration. The proposed model achieved an accuracy as high as 98% predicting COVID-19 cases for the next six days. When compared with other contemporary models CGPANN seems to perform well ahead in terms of accuracy. © 2022 IEEE.

Vaccinating a population is a changing programming problem

How best to apply vaccines to a population is an open problem. It is trivial to derive intuitive strategies, but until tested, their efficacy i s n ot k nown. T his p roblem i s particularly challenging when considering the dynamics of social contact networks and their changes over time. A system for automatically discovering tested vaccination strategies with evolutionary computation has been improved upon to include additional graph metrics and to generate vaccination strategies for dynamic graphs, something that is expected of real social networks within communities. The system’s ability to generate effective strategies was demonstrated along with a comparison of the strategies developed when fit t o a s tatic g raph v ersus a d ynamic g raph. I t w as observed that the additional computational resources required to generate strategies on a dynamic graph may not be necessary as strategies developed for static graphs performed similarly well;however, the authors are careful to acknowledge that results may differ significantly w hen a djusting t he s ystems m any parameters. © IEEE 2021.

Estimation of COVID-19 Epidemiology Curve of the United States Using Genetic Programming Algorithm.

Estimation of the epidemiology curve for the COVID-19 pandemic can be a very computationally challenging task. Thus far, there have been some implementations of artificial intelligence (AI) methods applied to develop epidemiology curve for a specific country. However, most applied AI methods generated models that are almost impossible to translate into a mathematical equation. In this paper, the AI method called genetic programming (GP) algorithm is utilized to develop a symbolic expression (mathematical equation) which can be used for the estimation of the epidemiology curve for the entire U.S. with high accuracy. The GP algorithm is utilized on the publicly available dataset that contains the number of confirmed, deceased and recovered patients for each U.S. state to obtain the symbolic expression for the estimation of the number of the aforementioned patient groups. The dataset consists of the latitude and longitude of the central location for each state and the number of patients in each of the goal groups for each day in the period of 22nd January 2020-3rd December 2020. The obtained symbolic expressions for each state are summed up to obtain symbolic expressions for estimation of each of the patient groups (confirmed, deceased and recovered). These symbolic expressions are combined to obtain the symbolic expression for the estimation of the epidemiology curve for the entire U.S. The obtained symbolic expressions for the estimation of the number of confirmed, deceased and recovered patients for each state achieved R2 score in the ranges 0.9406-0.9992, 0.9404-0.9998 and 0.9797-0.99955, respectively. These equations are summed up to formulate symbolic expressions for the estimation of the number of confirmed, deceased and recovered patients for the entire U.S. with achieved R2 score of 0.9992, 0.9997 and 0.9996, respectively. Using these symbolic expressions, the equation for the estimation of the epidemiology curve for the entire U.S. is formulated which achieved R2 score of 0.9933. Investigation showed that GP algorithm can produce symbolic expressions for the estimation of the number of confirmed, recovered and deceased patients as well as the epidemiology curve not only for the states but for the entire U.S. with very high accuracy.

Estimation of COVID-19 epidemic curves using genetic programming algorithm.

This paper investigates the possibility of the implementation of Genetic Programming (GP) algorithm on a publicly available COVID-19 data set, in order to obtain mathematical models which could be used for estimation of confirmed, deceased, and recovered cases and the estimation of epidemiology curve for specific countries, with a high number of cases, such as China, Italy, Spain, and USA and as well as on the global scale. The conducted investigation shows that the best mathematical models produced for estimating confirmed and deceased cases achieved R2 scores of 0.999, while the models developed for estimation of recovered cases achieved the R2 score of 0.998. The equations generated for confirmed, deceased, and recovered cases were combined in order to estimate the epidemiology curve of specific countries and on the global scale. The estimated epidemiology curve for each country obtained from these equations is almost identical to the real data contained within the data set.

Time Series Analysis and Forecast of the COVID-19 Pandemic in India using Genetic Programming.

COVID-19 declared as a global pandemic by WHO, has emerged as the most aggressive disease, impacting more than 90% countries of the world. The virus started from a single human being in China, is now increasing globally at a rate of 3% to 5% daily and has become a never ending process. Some studies even predict that the virus will stay with us forever. India being the second most populous country of the world, is also not saved, and the virus is spreading as a community level transmitter. Therefore, it become really important to analyse the possible impact of COVID-19 in India and forecast how it will behave in the days to come. In present work, prediction models based on genetic programming (GP) have been developed for confirmed cases (CC) and death cases (DC) across three most affected states namely Maharashtra, Gujarat and Delhi as well as whole India. The proposed prediction models are presented using explicit formula, and impotence of prediction variables are studied. Here, statistical parameters and metrics have been used for evaluated and validate the evolved models. From the results, it has been found that the proposed GEP-based models use simple linkage functions and are highly reliable for time series prediction of COVID-19 cases in India.